Microglia Morphological Categorization in a Rat Model of Neuroinflammation by Hierarchical Cluster and Principal … – Frontiers
Introduction Microglial cells are resident macrophages of myeloid origin in the central nervous system, which were introduced by Pío del Río-Hortega (Río-Hortega, 1919a,b,c,d; Sierra et al., 2016). He described the distribution and morphological phenotype of microglia and also recognized that ramified cells transformed into rod or amoeboid microglia in different situations of brain disease or pathology. In the normal brain they have been considered as “resting microglia”, but recent findings point that microglia are the most sensitive sensors in the brain, constantly scanning the parenchyma environment as surveillant cells (Nimmerjahn…
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